SKF-77,434

SKF-77,434
Tanımlayıcılar
CAS Numarası	104422-04-0;
PubChem CID	1241;
CompTox Bilgi Paneli (EPA)	DTXSID3043817 ;
Kimyasal ve fiziksel veriler
Formül	C19H21NO2

SKF-77,434 seçici bir dopamin D₁ reseptörü kısmi agonisti olarak hareket eden ve uyarıcı ve anorektik etkileri olan bir ilaçtır. SKF-81,297 ve 6-Br-APB gibi daha yüksek etkinliğe sahip diğer D₁ agonistlerinin aksine, SKF-77,434 kokain bağımlılığı için potansiyel bir tedavi olarak araştırılmıştır.^[1]^[2]^[3]^[4]^[5]^[6]

Kaynakça

^ "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29-38. October 1997. PMID 9336305.
^ "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017-26. June 2000. PMID 10869406.
^ "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208-16. September 2001. doi:10.1007/s002130100779. PMID 11594448.
^ "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362-70. April 2002. doi:10.1007/s00213-001-0976-z. PMID 11919663.
^ "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior. 81 (4): 843-8. August 2005. doi:10.1016/j.pbb.2005.06.006. PMID 16000217.
^ "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303-9. June 2006. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948.

[1] "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29-38. October 1997. PMID 9336305.

[2] "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017-26. June 2000. PMID 10869406.

[3] "Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys". Psychopharmacology. 157 (2): 208-16. September 2001. doi:10.1007/s002130100779. PMID 11594448.

[4] "Effects of chronic administration of the D1 receptor partial agonist SKF 77434 on cocaine self-administration in rhesus monkeys". Psychopharmacology. 160 (4): 362-70. April 2002. doi:10.1007/s00213-001-0976-z. PMID 11919663.

[5] "A comparison of the locomotor stimulant effects of D1-like receptor agonists in mice". Pharmacology, Biochemistry, and Behavior. 81 (4): 843-8. August 2005. doi:10.1016/j.pbb.2005.06.006. PMID 16000217.

[6] "Effects of dopamine D1-like receptor agonists on food-maintained operant behavior in rats". Behavioural Pharmacology. 17 (4): 303-9. June 2006. doi:10.1097/01.fbp.0000205015.67079.f7. PMID 16914948.

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