Ketoza eğilimli diyabet

Ketoza eğilimli diyabet
Ketoza eğilimli diyabet
Uzmanlık	Endokrinoloji

Ketoza eğilimli diyabet veya KED, tip 1 ve bazı tip 2 diyabetlerin bazı özelliklerine sahip olan diyabetin bir ara formudur. Bununla birlikte, erişkinlerde latent otoimmün diyabet, tip 1.5 olarak adlandırılan tip 1 formundan farklıdır.^[1]

KED, vücutta ketoasidozun bulunup bulunmamasına bağlı olarak tek bir özellik arzettiği ve ketoza eğilimli bir diyabet olduğunu doğruladığı için kolayca teşhis edilebilir.^[2] KPD, β-hücre otoantikorları (A + veya A−) ve β-hücre fonksiyonel rezervi (β + veya β−) varlığına veya yokluğuna bağlı olarak dört formda gelir.^[3]

Notlar

^ There is clearly a spectrum of clinical phenotypes among patients with islet autoantibodies who do not present with ketosis, including those termed “latent autoimmune diabetes in adults” (LADA) (30), “type 1.5 diabetes” (31,32,33), and “slowly progressing type 1 diabetes” (34). A similar spectrum exists in KPD that includes the very different phenotypes of A+β− and A+β+ KPD. A+β− KPD is synonymous with classic, early onset autoimmune type 1 diabetes; A+β+ KPD may overlap with LADA. However, there are differences between LADA, as recently defined by the Immunology of Diabetes Society, and A+β+ KPD patients; most importantly, the definition of LADA excludes patients who require insulin within the first 6 months after diagnosis, whereas the majority (90%) of A+β+ KPD patients present with DKA as the first manifestation of diabetes and therefore require insulin at the start. Balasubramanyam, A.; Nalini, R.; Hampe, C. S.; Maldonado, M. (2008). "Syndromes of ketosis-prone diabetes mellitus". Endocrinology Review. 29 (3). ss. 292–302. doi:10.1210/er.2007-0026. PMC 2528854 . PMID 18292467.
^ Leslie, R. D. G. (2008). "Diabetes classification: grey zones, sound and smoke: Action LADA 1". Diabetes/metabolism research and reviews. 24 (7). ss. 511–519. doi:10.1002/dmrr.877.
^ Nalini, Ramaswami (2008). "HLA class II alleles specify phenotypes of ketosis-prone diabetes". Diabetes Care. 31 (6). ss. 1195–1200. doi:10.2337/dc07-1971.

[1] There is clearly a spectrum of clinical phenotypes among patients with islet autoantibodies who do not present with ketosis, including those termed “latent autoimmune diabetes in adults” (LADA) (30), “type 1.5 diabetes” (31,32,33), and “slowly progressing type 1 diabetes” (34). A similar spectrum exists in KPD that includes the very different phenotypes of A+β− and A+β+ KPD. A+β− KPD is synonymous with classic, early onset autoimmune type 1 diabetes; A+β+ KPD may overlap with LADA. However, there are differences between LADA, as recently defined by the Immunology of Diabetes Society, and A+β+ KPD patients; most importantly, the definition of LADA excludes patients who require insulin within the first 6 months after diagnosis, whereas the majority (90%) of A+β+ KPD patients present with DKA as the first manifestation of diabetes and therefore require insulin at the start. Balasubramanyam, A.; Nalini, R.; Hampe, C. S.; Maldonado, M. (2008). "Syndromes of ketosis-prone diabetes mellitus". Endocrinology Review. 29 (3). ss. 292–302. doi:10.1210/er.2007-0026. PMC 2528854 . PMID 18292467.

[2] Leslie, R. D. G. (2008). "Diabetes classification: grey zones, sound and smoke: Action LADA 1". Diabetes/metabolism research and reviews. 24 (7). ss. 511–519. doi:10.1002/dmrr.877.

[3] Nalini, Ramaswami (2008). "HLA class II alleles specify phenotypes of ketosis-prone diabetes". Diabetes Care. 31 (6). ss. 1195–1200. doi:10.2337/dc07-1971.

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