Alfa-2C adrenerjik reseptör

ADRA2C olarak da bilinen alfa-2C adrenerjik reseptör, bir alfa-2 adrenerjik reseptördür ve aynı zamanda onu kodlayan insan genini belirtir.^[1]

Gen

Bu gen, kodlamasında veya çevrilmemiş dizilerinde hiçbir intron içermeyen alfa2C alt tipini kodlar.^[1]

Ligandlar

Agonistler

(R)-3-Nitrobifenilin^[2]

Antagonistler

BMY 7378 (ayrıca α<sub id="mwQg">1D</sub> antagonisti)^[3]
JP-1302: α2A, α2B, α2C'ye göre seçici^[4]
N- {2-[4-(2,3-dihidro-benzo[1,4]dioksin-2-ilmetil)-[1,4]diazepan-1-il]-etil}-2-fenoksi-nikotinamid^[5]
Ketiapin^[6]
Risperidon
Spiroksatrin
Yohimbin türevleri 9 ve 10: α2A, α2B ve α1 alt tiplerine göre >43 kat seçicilik^[7]
Brekspiprazol

Kaynakça

^ ^a ^b "Entrez Gene: ADRA2C adrenergic, alpha-2C-, receptor". 2 Kasım 2008 tarihinde kaynağından arşivlendi.
^ "Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist". Journal of Medicinal Chemistry. 50 (16): 3964-8. August 2007. doi:10.1021/jm061487a. PMID 17630725.
^ "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic and Autacoid Pharmacology. 25 (4): 135-41. 2005. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444.
^ "Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302". Br. J. Pharmacol. 150 (4): 391-402. 2007. doi:10.1038/sj.bjp.0707005. PMC 2189732 . PMID 17220913.
^ "Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist". Bioorg. Med. Chem. Lett. 18 (20): 5689-93. 2008. doi:10.1016/j.bmcl.2008.08.055. PMID 18799310.
^ "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology. 33 (10): 2303-12. September 2008. doi:10.1038/sj.npp.1301646. PMID 18059438.
^ "Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands". J. Pharmacol. Exp. Ther. 319 (2): 739-48. November 2006. doi:10.1124/jpet.106.105981. PMID 16873606.

[entrez-1] "Entrez Gene: ADRA2C adrenergic, alpha-2C-, receptor". 2 Kasım 2008 tarihinde kaynağından arşivlendi.

[pmid17630725-2] "Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist". Journal of Medicinal Chemistry. 50 (16): 3964-8. August 2007. doi:10.1021/jm061487a. PMID 17630725.

[pmid16176444-3] "The alpha (1D)-adrenoceptor antagonist BMY 7378 is also an alpha (2C)-adrenoceptor antagonist". Autonomic and Autacoid Pharmacology. 25 (4): 135-41. 2005. doi:10.1111/j.1474-8673.2005.00342.x. PMID 16176444.

[pmid17220913-4] "Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302". Br. J. Pharmacol. 150 (4): 391-402. 2007. doi:10.1038/sj.bjp.0707005. PMC 2189732 . PMID 17220913.

[pmid18799310-5] "Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist". Bioorg. Med. Chem. Lett. 18 (20): 5689-93. 2008. doi:10.1016/j.bmcl.2008.08.055. PMID 18799310.

[pmid18059438-6] "N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity". Neuropsychopharmacology. 33 (10): 2303-12. September 2008. doi:10.1038/sj.npp.1301646. PMID 18059438.

[pmid16873606-7] "Tethered yohimbine analogs as selective human alpha2C-adrenergic receptor ligands". J. Pharmacol. Exp. Ther. 319 (2): 739-48. November 2006. doi:10.1124/jpet.106.105981. PMID 16873606.

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